研究室の紹介

研究室メンバー

三橋　隆章
MITSUHASHI Takaaki

特任助教（分子研）

プロフィール

2014年3月　　東京大学薬学部卒業
2016年3月　　東京大学大学院薬学系研究科修士課程修了
2016年9月　　東京大学大学院薬学系研究科博士課程進学
(2017年4月-　 日本学術振興会特別研究員 DC1)
2019年9月　　東京大学大学院薬学系研究科博士課程修了
2019年10月-　東京大学大学院工学系研究科　特任助教
2020年4月-     分子科学研究所 藤田G 特任助教
 

論文リスト

  1. Mitsuhashi, T., Abe, I. “Sesterterpenoids.” Progress in the Chemistry of Organic Natural Products, Springer, manuscript in preparation (2019)

  2. Powers, Z., Mitsuhashi, T., Scharf, A., Cheng, A., Yang, F., Barra. L., Taniguchi, Y., Kikuchi, T., Fujita, M., Abe, I., Porco, J. A. Jr. “TBA.” submitted (2019)

  3. Hoshino, S., Mitsuhashi, T., Kikuchi, T., Wong, C. P., Morita, H., Awakawa, T., Fujita, M., Abe, I. “Structural elucidation of tenebrathin: cytotoxic C5-substituted g-pyrone with nitroaryl side chain from Streptoalloteichus tenebrarius.” Org. Lett. 21, in press (2019)

  4. Sato, H., Mitsuhashi, T., Yamazaki, M., Abe, I., Uchiyama, M. “Inherent atomic mobility changes in carbocation intermediates during the sesterterpene cyclization cascade.“ Beilstein J. Org. Chem. 15, in press (2019)

  5. Nakashima, Y.,† Mitsuhashi, T.,† Matsuda, Y.,† Senda, M., Sato, H., Yamazaki, M., Uchiyama, M., Senda, T., Abe, I. “Structural and computational bases for dramatic skeletal rearrangement in anditomin biosynthesis.” J. Am. Chem. Soc. 140, 9743-9750

(2018) †co-first author

  1. Mitsuhashi, T., Kikuchi, T., Hoshino, S., Ozeki, M., Awakawa, T., Shi, S.-P., Fujita, M., Abe, I. “The crystalline sponge method enabled the investigation of a prenyltransferase-terpene synthase chimeric enzyme, whose product exhibits broadened NMR signals.” Org. Lett. 20, 5606-5609 (2018)

  2. Sato, H., Mitsuhashi,T., Abe, I., Uchiyama, M. "Computational studies on biosynthetic carbocation rearrangements leading to quiannulatene: initial conformation regulates biosynthetic route, stereochemistry, and type of skeleton." Angew. Chem. Int. Ed. 57, 14752-14757 (2018)

  3. Mitsuhashi T., Abe, I. “Chimeric terpene synthases possessing both terpene cyclization and prenyltransfer activities.” ChemBioChem, 19, 1106-1114 (2018)

  1. Mitsuhashi, T.,† Rinkel, J.,† Okada, M., Abe, I., Dickschat, J. S. "Mechanistic characterization of two chimeric sesterterpene synthases from Penicillium." Chem. Eur. J. 23, 10053-10057 (2017) †co-first author

  2. Mitsuhashi, T., Okada, M., Abe, I. "Identification of chimeric abg diterpene synthases possessing both type II terpene cyclase and prenyltransferase activities." ChemBioChem, 18, 2104-2109 (2017)

  3. Okada, M., Matsuda, Y., Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I. "Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis." J. Am. Chem. Soc. 138, 10011-10018 (2016)

  4. Matsuda, Y.,† Mitsuhashi,T.,† Lee, S.,† Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M., Abe, I. "Astellifadiene, a unique tetracyclic fungal sesterterpene: structure determination by an NMR-coupled crystalline sponge method and elucidation of its biosynthesis." Angew. Chem. Int. Ed. 55, 5785-5788 (2016) †co-first author

  5. Qin, B., Matsuda, Y., Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T., Abe, I. "An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping." Angew. Chem. Int. Ed. 55, 1658-1661 (2016)

  6. Matsuda, Y., Quan, Z., Mitsuhashi, T., Li, C., Abe, I. "Cytochrome P450 for citreohybridonol synthesis: oxidative derivatization of andrastin scaffold." Org. Lett. 18, 296-299 (2016)

  7. Matsuda, Y.,† Mitsuhashi, T.,† Quan, Z., Abe, I. "Molecular basis for stellatic acid biosynthesis: a genome mining approach for discovery of sesterterpene synthases." Org. Lett. 17, 4644-4647 (2015) †co-first author

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