Profile

[researchmap] [ORCiD] [publons]

2023 Dec. Project Lecturer (The University of Tokyo)
2017 Mar. Assitant Professor (The University of Tokyo)
2015 Apr.–2017 Feb. Researcher, Asahi Kasei Corporation
2015 Mar. Ph.D. with Prof. M. Fujita (The University of Tokyo)
2012 Mar. Master (The University of Tokyo)
2010 Mar. Bachelor (The University of Tokyo)
 

Awards

2023 The 72nd CSJ Award for Young Chemists
2022 The 36th CSJ Young Scholar Lecture
2021 The 15th PCCP Prize
2019 The 7th Asian Conference on Coordination Chemistry Early Career Researcher Presentation Award
 

Publications

• Selective Synthesis and Functionalization of an Acyclic Methylene-Bridged-Arene Trimer in a Cage
  H. Takezawa, K. Iizuka, M. Fujita
  Angew. Chem. Int. Ed. 2024, 63, e202319140. [ 10.1002/anie.202319140 ]
• Chemical Site-Differentiation of Calix[4]arenes through Enforced Conformations by Confinement in a Cage
  K. Iizuka, H. Takezawa, M. Fujita
  J. Am. Chem. Soc. 2023, 145, 25971–25975. [ 10.1021/jacs.3c10720 ]
• Tetradehydro-Diels-Alder Reactions of Flexible Arylalkynes via Folding Inside a Molecular Cage
  G. R. Genov, H. Takezawa, H. Hayakawa, M. Fujita
  J. Am. Chem. Soc. 2023, 145, 17013–17017. [ 10.1021/jacs.3c06301 ]
• Synthetic Modulation of an Unstable Dehydrosecodine-type Intermediate and Its Encapsulation into a Confined Cavity Enable Its X-ray Crystallographic Observation
  G. Tay, T. Wayama, H. Takezawa, S. Yoshida, S. Sato, M. Fujita, H. Oguri
  Angew. Chem. Int. Ed. 2023, 62, e202305122. [ 10.1002/anie.202305122 ]
• Self-Assembled Coordination Cage Enhances Reactivity of Confined Amides via Mechanical Bond-Twisting
  H. Tamura, H. Takezawa, M. Fujita, H. Ishikita
  Phys. Chem. Chem. Phys. 2022, 24, 21367–21371. [ 10.1039/D2CP03126D ]
• Selective Confinement of Rare-Earth-Metal Hydrates by a Capped Metallo-Cage under Aqueous Conditions
  R. Tabuchi, H. Takezawa, M. Fujita
  Angew. Chem. Int. Ed. 2022, 61, e202208866. [ 10.1002/anie.202208866 ]
• Electrophilic Spirocyclization of a 2-Biphenylacetylene via Conformational Fixing within a Hollow-Cage Host
  H. Takezawa, Y. Fujii, T. Murase, M. Fujita
  Angew. Chem. Int. Ed. 2022, 61, e202203970. [ 10.1002/anie.202203970 ]
• Molecular Confinement Effects by Self-Assembled Coordination Cages
  H. Takezawa, M. Fujita
  Bull. Chem. Soc. Jpn. 2021, 94, 2351–2369. [ 10.1246/bcsj.20210273 ]
• An Ir₃L₂ complex with anion binding pockets: photocatalytic E–Z isomerization via molecular recognition
  H. Sunohara, K. Koyamada, H. Takezawa, M. Fujita
  Chem. Commun. 2021, 57, 9300–9302. [ 10.1039/D1CC03620C ]
• Confinement of Water-Soluble Cationic Substrates in a Cationic Molecular Cage by Capping the Portals with Tripodal Anions
  H. Takezawa, R. Tabuchi, H. Sunohara, M. Fujita
  J. Am. Chem. Soc. 2020, 142, 17919-17922. [ 10.1021/jacs.0c08835 ]
• A Robust Double-Walled Knotted Cage Revealed Guest Binding through Adaptive Portal Expansion
  Y. Tamura, H. Takezawa, M. Fujita
  Chem. Lett. 2020, 49, 912-914. [ 10.1246/cl.200282 ]
• Enhanced reactivity of twisted amides inside a molecular cage
  H. Takezawa, K. Shitozawa, M. Fujita
  Nat. Chem. 2020, 12, 574-578. [ 10.1038/s41557-020-0455-y ]
• A Double-Walled Knotted Cage for Guest-Adaptive Molecular Recognition
  Y. Tamura, H. Takezawa, M. Fujita
  J. Am. Chem. Soc. 2020, 142, 5504-5508. [ 10.1021/jacs.0c00459 ]
• Demethylenation of Cyclopropanes via Photo-Induced Guest-to-Host Electron Transfer in a M₆L₄ Cage
  W. Cullen, H. Takezawa, M. Fujita
  Angew. Chem. Int. Ed. 2019, 58, 9171-9173. [ 10.1002/anie.201904752 ]
• Site-Selective Functionalization of Linear Diterpenoids through U-Shaped Folding in a Confined Artificial Cavity
  H. Takezawa, T. Kanda, H. Nanjo, M. Fujita
  J. Am. Chem. Soc. 2019, 141, 5112-5115. [ 10.1021/jacs.9b00131 ]
• Microgram-scale X-ray Structure Analysis of Small Molecules via High-throughput Co-crystallization
  Y. Tamura, H. Takezawa, Y. Domoto, M. Fujita
  Chem. Lett. 2018, 47, 617-619. [ 10.1246/cl.180082 ]
• Halogen-Bond-Assisted Guest Inclusion in a Synthetic Cavity
  H. Takezawa, T. Murase, G. Resnati, P. Metrangolo, M. Fujita
  Angew. Chem. Int. Ed. 2015, 54, 8411-8414. [ 10.1002/anie.201500994 ]
• Cavity-Directed Chromism of Phthalein Dyes
  H. Takezawa, S. Akiba, T. Murase, M. Fujita
  J. Am. Chem. Soc. 2015, 137, 7043-7046. [ 10.1021/jacs.5b03618 ]
• Recognition of Polyfluorinated Compounds Through Self-Aggregation in a Cavity
  H. Takezawa, T. Murase, G. Resnati, P. Metrangolo, M. Fujita
  J. Am. Chem. Soc. 2014, 136, 1786|1788. [ 10.1021/ja412893c ]
• Temporary and Permanent Trapping of the Metastable Twisted Conformer of an Overcrowded Chromic Alkene via Encapsulation
  H. Takezawa, T. Murase, M. Fujita
  J. Am. Chem. Soc. 2012, 134, 17420-17423. [ 10.1021/ja308101a ]

 

Invited Lecture, etc. (International)

"Visualization of Confinement Effects in Coordination Cages via Sticker-Induced Crystallization"
ICPAC Bali 2023, Bali, Indonesia, Sept. 13, 2023

"Molecular Manipulation by Confinement in a Coordination Cage for Precise Molecular Conversion"
Japan Society of Coordination Chemistry 72nd Annual Meeting,
Symposium "Advanced Design of Functional Nanospaces for Molecular Recognition and Conversion" Fukuoka, Japan, Sept. 26, 2022