研究室の紹介

Lab. Members

Tomohisa Sawada

Lecturer

Profile

2016 Jul.- Lecturer (The Univ. of Tokyo)
2011 Oct.- 2016 Jun. Assist. Prof. (The Univ. of Tokyo)
2010 Apr.-2011 Oct. Postdoc. with Prof. S. H. Gellman (Univ. of Wisconsin-Madison)
2010 Mar. Ph. D. with Prof. M. Fujita (The Univ. of Tokyo)
2007 Mar. Master (The Univ. of Tokyo)
2005 Mar. Bachelor (The Univ. of Tokyo)

Research Projects

1.  Metal-directed Folding and Assembly
We have developed a new synthetic strategy for unique nanostructures where concomitant processes of short peptide folding an
d assembly are triggered by metal coordination.

2.  Creation and Functionalization of Self-assembled Hosts
We have created self-assembled coordination cages and capsules that show excellent molecular recognition abilities.

List of Publications

  • Self-Assembly of a Peptide [2]Catenane through Ω-Loop Folding
    T. Sawada, Y. Inomata, M. Yamagami, M. Fujita
    Chem. Lett. 2017, 46, 1119-1121. [ 10.1246/cl.170438 ]
  • Porous Peptide Complexes by a Folding-and-Assembly Strategy
    T. Sawada, M. Yamagami, S. Akinaga, T. Miyaji, M. Fujita
    Chem. Asian J. 2017, 12, 1715-1718. [ 10.1002/asia.201700458 ]
  • Selective Co-Encapsulation Inside an M6L4 Cage
    S. H. A. M. Lenders, R. Becker, T. Kumpulainen, B. de Bruin, T. Sawada, T. Kato, M. Fujita, J. N. H. Reek
    Chem. Eur. J. 2016, 22, 15468-15474. [ 10.1002/chem.201603017 ]
  • Capsule–Bowl Conversion Triggered by a Guest Reaction
    S. Wang, T. Sawada, M. Fujita
    Chem. Commun. 2016, 52, 11653-11656. [ 10.1039/C6CC06551A ]
  • Compressed Corannulene in a Molecular Cage
    B. M. Schmidt, T. Osuga, T. Sawada, M. Hoshino, M. Fujita
    Angew. Chem. Int. Ed. 2016, 55, 1561-1564. [ 10.1002/anie.201509963 ]
  • Capsule-Capsule Conversion by Guest Encapsulation
    S. Wang, T. Sawada, K. Ohara, K. Yamaguchi, M. Fujita
    Angew. Chem. Int. Ed. 2016, 55, 2063-2066. [ 10.1002/anie.201509278 ]
  • Peptide [4]Catenane by Folding and Assembly
    T. Sawada, M. Yamagami, K. Ohara, K. Yamaguchi, M. Fujita
    Angew. Chem. Int. Ed. 2016, 55, 4519-4522. [ 10.1002/anie.201600480 ]
  • Mutual Induced Fit in a Synthetic Host-Guest System
    T. Sawada, H. Hisada, M. Fujita
    J. Am. Chem. Soc. 2014, 136, 4449-4451. [ 10.1021/ja500376x ]
  • Coordination-Driven Folding and Assembly of a Short Peptide into a Protein-like Two-Nanometer-Sized Channel
    T. Sawada, A. Matsumoto, M. Fujita
    Angew. Chem. Int. Ed. 2014, 53, 7228-7232. [ 10.1002/anie.201403506 ]
  • A Single Watson-Crick GC Base Pair in Water: Aqueous Hydrogen Bonds in Hydrophobic Cavities
    T. Sawada and M. Fujita
    J. Am. Chem. Soc. 2010, 132, 7194?7201. [ 10.1021/ja101718c ]
  • Inducing -Helices in Short Oligopeptides through Binding by an Artificial Hydrophobic Cavity
    C. Dolain, Y. Hatakeyama, T. Sawada, S. Tashiro, and M. Fujita
    J. Am. Chem. Soc. 2010, 132, 5564-5565. [ 10.1021/ja100585w ]
  • Minimal Nucleotide Duplex Formation in Water through Enclathration in Self-Assembled Hosts
    T. Sawada, M. Yoshizawa, S. Sato, and M. Fujita
    Nature Chem. 2009, 1, 53-56. [ 10.1038/nchem.100 ]
  • Conformational Preferences of Short Peptide Fragments
    Y. Hatakeyama, T. Sawada, M. Kawano, and M. Fujita
    Angew. Chem. Int. Ed. 2009, 48, 8695-8698. [ 10.1002/anie.200903563 ]
  • Ultramacrocyclization through Reversible Catenation
    A. Hori, T. Sawada, K. Yamashita, and M. Fujita
    Angew. Chem. Int. Ed. 2005, 44, 4896-4899. [ 10.1002/anie.200501559 ]
  1. Structural Mimicry of the α-Helix in Aqueous Solution with an Isoatomic α/β/γ-Peptide Backbone
    T. Sawada and S. H. Gellman
    J. Am. Chem. Soc. 2011, 133, 7336-7339.

  2. Topologically Matching Supramolecular n/p-Heterojunction Architectures
    R. Bhosale, A. Perez-Velasco, V. Ravikumar, R. S. K. Kishore, O. Kel, A. Gomez-Casado, P. Jonkheijm, J. Huskens, P. Maroni, M. Borkovec, T. Sawada, E. Vauthey, N. Sakai, and S. Matile
    Angew. Chem. Int. Ed. 2009, 48, 6461-6464.